{"id":416080,"date":"2020-02-13T11:35:01","date_gmt":"2020-02-13T10:35:01","guid":{"rendered":"http:\/\/hudo.com\/si\/?p=416080"},"modified":"2020-02-13T11:35:01","modified_gmt":"2020-02-13T10:35:01","slug":"slovenski-raziskovalci-pomembnega-napredka-pri-razumevanju-delovanja-scitnice","status":"publish","type":"post","link":"https:\/\/hudo.com\/si\/aktualno\/slovenski-raziskovalci-pomembnega-napredka-pri-razumevanju-delovanja-scitnice\/","title":{"rendered":"Slovenski raziskovalci do pomembnega napredka pri razumevanju delovanja \u0161\u010ditnice"},"content":{"rendered":"<p>Raziskovalci Instituta Jo\u017eef Stefan in Centra odli\u010dnosti za integrirane pristope v kemiji in biologiji proteinov (CIPKeBiP) Du\u0161an Turk, Ajda Taler-Ver\u010di\u010d in Miha Renko so v sodelovanju z raziskovalci iz Cambridgea, Berlina in Bristola prvi\u010d s pomo\u010djo krioelektronske mikroskopije v celotni dol\u017eini predstavili strukturo tiroglobulina, proteina, iz katerega nastanejo \u0161\u010ditni\u010dni hormoni.<\/p>\n<p>Raziskovalci po navedbah IJS pri\u010dakujejo, &#8220;da bo objavljeno delo pomembno prispevalo k razumevanju delovanja \u0161\u010ditnice in bo zato postalo del u\u010dbenikov biokemije in endokrinologije. Nadalje pa bo pomagalo razlo\u017eiti, zakaj in kako pride do te\u017eav pri delovanju \u0161\u010ditnice, in jih tako \u0161e u\u010dinkoviteje zdraviti in nadzirati.&#8221;<\/p>\n<p>Izsledke \u0161tudije je objavila mednarodna znanstvena revija Nature v \u010dlanku z naslovom Struktura \u010dlove\u0161kega tiroglobulina, nahaja se na spletnem naslovu\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-1995-4?proof=trueMay\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.nature.com\/articles\/s41586-020-1995-4?proof=trueMay<\/a>.<\/p>\n<p>Tiroglobulin je protein, iz katerega v \u0161\u010ditnici nastajata hormona T3 in T4, ki uravnavata porabo energije v na\u0161ih celicah. Hormona in tiroglobulin so edine molekule v na\u0161em organizmu, ki vsebujejo jod, zato je jod klju\u010dni element in nujno potreben za razvoj in pravilno delovanje organizma. Vloga tiroglobulina v \u0161\u010ditnici pa ni le nastanek hormonov, temve\u010d tudi shranjevanje joda za obdobja, ko ga s prehrano ne vnesemo dovolj.<\/p>\n<p>Delovanje \u0161\u010ditnice je dobro raziskano, kar stroki omogo\u010da dobro nadziranje s \u0161\u010ditnico povezanih te\u017eav. Do danes pa je bilo neznano, kako hormoni v \u0161\u010ditnici dejansko nastanejo.<\/p>\n<p>\u010clove\u0161ki tiroglobulin je velikanska molekula, ki jo sestavljata dve verigi iz 2768 aminokislin oziroma skupno 5536 aminokislin. Struktura tiroglobulina, dolo\u010dena s krioelektronsko mikroskopijo, je razkrila, da ima ta molekula le sedem mest, na katerih nastanejo hormoni. Vsaka molekula hormona nastane iz dveh aminokislin, imenovanih tirozin. Nastale hormone z razgradnjo tiroglobulina izlu\u0161\u010dijo encimi, proteaze, ki ga razgradijo na osnovne gradnike &#8211; aminokisline.<\/p>\n<p>Novo odkrita struktura tiroglobulina je po navedbah IJS plod skoraj dveh desetletij prizadevanj in revolucije v krioelektronski mikroskopiji. Pomemben korak pa je bila tudi priprava proteinskega vzorca iz sintetskega genetskega zapisa v sesalskih celi\u010dnih kulturah.<\/p>\n<p>Iz 3D-strukture so raziskovalci lahko prepoznali aminokislinske preostanke tirozina, ki tvorijo hormone, z mutiranjem preostankov pa so njihovo vlogo lahko tudi dokazali. Reaktivna mesta tirozinskih preostankov so uspe\u0161no prenesli tudi na bakterijski protein in s tem pokazali, da je umestitev sinteze hormonov T3 in T4 v \u0161\u010ditnico bistvena za uravnavanje in izvajanje sinteze hormonov in ne sama molekula tiroglobulina in udele\u017eenih encimov.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Slovenski raziskovalci so skupaj s kolegi iz Velike Britanije in Nem\u010dije prvi\u010d v celoti predstavili strukturo tiroglobulina &#8211; proteina, iz katerega nastanejo \u0161\u010ditni\u010dni hormoni. Izsledki njihove \u0161tudije bodo pomembno prispevali k razumevanju delovanja \u0161\u010ditnice ter k bolj u\u010dinkovitemu zdravljenju in nadzoru te\u017eav s \u0161\u010ditnico, so sporo\u010dili z IJS.<\/p>\n","protected":false},"author":8,"featured_media":353608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1179],"tags":[10624,5333,1595,11812],"source":[4511],"supertag":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Slovenski raziskovalci do pomembnega napredka pri razumevanju delovanja \u0161\u010ditnice - Hudo Slovenija<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/hudo.com\/si\/aktualno\/slovenski-raziskovalci-pomembnega-napredka-pri-razumevanju-delovanja-scitnice\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Slovenski raziskovalci do pomembnega napredka pri razumevanju delovanja \u0161\u010ditnice - Hudo Slovenija\" \/>\n<meta property=\"og:description\" content=\"Slovenski raziskovalci so skupaj s kolegi iz Velike Britanije in Nem\u010dije prvi\u010d v celoti predstavili strukturo tiroglobulina - proteina, iz katerega nastanejo \u0161\u010ditni\u010dni hormoni. Izsledki njihove \u0161tudije bodo pomembno prispevali k razumevanju delovanja \u0161\u010ditnice ter k bolj u\u010dinkovitemu zdravljenju in nadzoru te\u017eav s \u0161\u010ditnico, so sporo\u010dili z IJS.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/hudo.com\/si\/aktualno\/slovenski-raziskovalci-pomembnega-napredka-pri-razumevanju-delovanja-scitnice\/\" \/>\n<meta property=\"og:site_name\" content=\"Hudo Slovenija\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/hudo.si\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-13T10:35:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/hudo.com\/si\/wp-content\/uploads\/sites\/2\/2018\/01\/profimedia-0159741701.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1250\" \/>\n\t<meta property=\"og:image:height\" content=\"833\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"M. 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